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Cholinergic Basal Forebrain Systems in the Primate Central Nervous System-19:Anatomy, Connectivity, Neurochemistry, Aging, Dementia, and Experimental Therapeutics

Mufson, Elliott J. ; Kordower, Jeffrey H.

Functional Neurobiology of Aging, Chapter 19, pp.243-281

ISBN: 978-0-12-351830-9 ; DOI: 10.1016/B978-012351830-9/50021-4

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  • Nhan đề:
    Cholinergic Basal Forebrain Systems in the Primate Central Nervous System-19:Anatomy, Connectivity, Neurochemistry, Aging, Dementia, and Experimental Therapeutics
  • Tác giả: Mufson, Elliott J. ; Kordower, Jeffrey H.
  • Là 1 phần của: Functional Neurobiology of Aging, Chapter 19, pp.243-281
  • Mô tả: This chapter reviews the central cholinergic projection neurons in the primate brain and their relationship to development, aging, disease, and therapeutics. It also gives a clear and complete historical discussion of the definition of the essential basal forebrain cholinergic system. A heterogeneous collection of telencephalic structures situated on the medial and ventral regions of the cerebral hemispheres collectively make up the basal forebrain in the primate brain. Usually, this area is complicated and contains structures such as the septal area and the vertical and horizontal limbs of the diagonal band of Broca along with the region termed as the substantia innominata, which is the most anatomically complex. The chapter also discusses the fact that among the great diversity of neuronal populations within the basal forebrain, the cholinergic corticopetal projection neurons have received attention because they have considerably reduced the Alzheimer disease, as well as because of their innate relationship with the neurotrophic substance, nerve growth factor (NGF), and high and low affinity receptors.
  • Năm xuất bản: 2001
  • Ngôn ngữ: English;Italian;German
  • Số nhận dạng: ISBN: 978-0-12-351830-9 ; DOI: 10.1016/B978-012351830-9/50021-4

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