skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation

Yoshitaka Kihira ; Mariko Miyake ; Manami Hirata ; Yoji Hoshina ; Kana Kato ; Hitoshi Shirakawa ; Hiroshi Sakaue ; Noriko Yamano ; Yuki Izawa-Ishizawa ; Keisuke Ishizawa ; Yasumasa Ikeda ; Koichiro Tsuchiya ; Toshiaki Tamaki ; Shuhei Tomita

PLoS ONE, 01 January 2014, Vol.9(4), p.e93856 [Tạp chí có phản biện]

E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0093856

Truy cập trực tuyến

Phiên bản sẵn có
Trích dẫn Trích dẫn bởi
  • Nhan đề:
    Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation
  • Tác giả: Yoshitaka Kihira ; Mariko Miyake ; Manami Hirata ; Yoji Hoshina ; Kana Kato ; Hitoshi Shirakawa ; Hiroshi Sakaue ; Noriko Yamano ; Yuki Izawa-Ishizawa ; Keisuke Ishizawa ; Yasumasa Ikeda ; Koichiro Tsuchiya ; Toshiaki Tamaki ; Shuhei Tomita
  • Chủ đề: Sciences (General)
  • Là 1 phần của: PLoS ONE, 01 January 2014, Vol.9(4), p.e93856
  • Mô tả: It is known that obese adipose tissues are hypoxic and express hypoxia-inducible factor (HIF)-1[alpha]. Although some studies have shown that the expression of HIF-1[alpha] in adipocytes induces glucose intolerance, the mechanisms are still not clear. In this study, we examined its effects on the development of type 2 diabetes by using adipocyte-specific HIF-1[alpha] knockout (ahKO) mice. ahKO mice showed improved glucose tolerance compared with wild type (WT) mice. Macrophage infiltration and mRNA levels of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor [alpha] (TNF[alpha]) were decreased in the epididymal adipose tissues of high fat diet induced obese ahKO mice. The results indicated that the obesity-induced adipose tissue inflammation was suppressed in ahKO mice. In addition, in the ahKO mice, serum insulin levels were increased under the free-feeding but not the fasting condition, indicating that postprandial insulin secretion was enhanced. Serum glucagon-like peptide-1 (GLP-1) levels were also increased in the ahKO mice. Interestingly, adiponectin, whose serum levels were increased in the obese ahKO mice compared with the obese WT mice, stimulated GLP-1 secretion from cultured intestinal L cells. Therefore, insulin secretion may have been enhanced through the adiponectin-GLP-1 pathway in the ahKO mice. Our results suggest that the deletion of HIF-1[alpha] in adipocytes improves glucose tolerance by enhancing insulin secretion through the GLP-1 pathway and by reducing macrophage infiltration and inflammation in adipose tissue.
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0093856

Đang tìm Cơ sở dữ liệu bên ngoài...