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Clinical Perspectives of Mesenchymal Stem Cells

Jan Kramer ; Francesco Dazzi ; Massimo Dominici ; Peter Schlenke ; Wolfgang Wagner

Stem cells international, 01 January 2012, Vol.2012 [Tạp chí có phản biện]

ISSN: 1687-966X ; E-ISSN: 1687-9678 ; DOI: 10.1155/2012/684827

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  • Nhan đề:
    Clinical Perspectives of Mesenchymal Stem Cells
  • Tác giả: Jan Kramer ; Francesco Dazzi ; Massimo Dominici ; Peter Schlenke ; Wolfgang Wagner
  • Chủ đề: Biology
  • Là 1 phần của: Stem cells international, 01 January 2012, Vol.2012
  • Mô tả: Mesenchymal stem cells (MSCs) raise high hopes for regenerative medicine—in fact, they have already paved their way to a large number of clinical trials for a broad range of diseases. So far, several studies provided promising results, but this relatively new area of research requires further validation as some of the studies revealed varying outcomes. This might be a result of the heterogeneity of MSC cultures and absence of reliable protocols for isolation of the naïve stem cell fraction. MSCs are not precisely defined on a molecular level. They can be isolated from many tissues under different culture conditions—yet, they comprise multiple subpopulations and only a subset reveals multipotent differentiation capacity into at least adipogenic, chondrogenic, and osteogenic lineages. Notably, the composition of subpopulations seems to be greatly affected by culture methods and in the course of culture expansion.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 1687-966X ; E-ISSN: 1687-9678 ; DOI: 10.1155/2012/684827

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