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News & Views: Bring on the Biomarkers--It's Time for the "Big Science" Approach

Zhang, Y.

Clinical Chemistry, 06/01/2011, Vol.57(6), pp.928-929 [Tạp chí có phản biện]

ISSN: 0009-9147 ; E-ISSN: 1530-8561 ; DOI: http://dx.doi.org/10.1373/clinchem.2011.166058

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  • Nhan đề:
    News & Views: Bring on the Biomarkers--It's Time for the "Big Science" Approach
  • Tác giả: Zhang, Y.
  • Chủ đề: Medicine
  • Là 1 phần của: Clinical Chemistry, 06/01/2011, Vol.57(6), pp.928-929
  • Mô tả: In the past decade, more than 150 000 publications have documented thousands of newly discovered candidate biomarkers representing hundreds of millions of dollars in research investment, yet only about 100 biomarkers have demonstrated potential clinical utility. Additionally, although large-scale and high-throughput technologies such as proteomics and genomics have held special promise for the discovery of novel biomarkers that can be used clinically, these promises have yet to be fulfilled. In a recent article in Nature (1), Dr. George Poste, the chief scientist at the Complex Adaptive Systems Initiative and Regents Professor of Health Innovation at Arizona State University, argues that “the dismal patchwork of fragmented research on disease-associated biomarkers should be replaced by a coordinated ‘big science’ approach.” Highlights of this article are summarized below. Major components …
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0009-9147 ; E-ISSN: 1530-8561 ; DOI: http://dx.doi.org/10.1373/clinchem.2011.166058

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