skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

Hsu, P. P. ; Kang, S. A. ; Rameseder, J. ; Zhang, Y. ; Ottina, K. A. ; Lim, D. ; Peterson, T. R. ; Choi, Y. ; Gray, N. S. ; Yaffe, M. B. ; Marto, J. A. ; Sabatini, D. M.

Science, 06/10/2011, Vol.332(6035), pp.1317-1322 [Tạp chí có phản biện]

ISSN: 0036-8075 ; E-ISSN: 1095-9203 ; DOI: http://dx.doi.org/10.1126/science.1199498

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
  • Tác giả: Hsu, P. P. ; Kang, S. A. ; Rameseder, J. ; Zhang, Y. ; Ottina, K. A. ; Lim, D. ; Peterson, T. R. ; Choi, Y. ; Gray, N. S. ; Yaffe, M. B. ; Marto, J. A. ; Sabatini, D. M.
  • Chủ đề: Growth Factors -- Physiological Aspects ; Rapamycin -- Physiological Aspects ; Rapamycin -- Genetic Aspects ; Proteins -- Physiological Aspects ; Proteomics -- Research
  • Là 1 phần của: Science, 06/10/2011, Vol.332(6035), pp.1317-1322
  • Mô tả: The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We defined the mTOR-regulated phosphoproteome by quantitative mass spectrometry and characterized the primary sequence motif specificity of mTOR using positional scanning peptide libraries. We found that the phosphorylation response to insulin is largely mTOR dependent and that mTOR exhibits a unique preference for proline, hydrophobic, and aromatic resiclues at the +1 position. The adaptor protein Grb10 was identified as an mTORC1 substrate that mediates the inhibition of phosphoinositide 3-kinase typical of cells lacking tuberous sclerosis complex 2 (TSC2), a tumor suppressor and negative regulator of mTORC1. Our work clarifies how mTORC1 inhibits growth factor signaling and opens new areas of investigation in mTOR biology. 10.1126/science.1199498
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0036-8075 ; E-ISSN: 1095-9203 ; DOI: http://dx.doi.org/10.1126/science.1199498

Đang tìm Cơ sở dữ liệu bên ngoài...