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McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR

Fuhrmann, J. ; Schmidt, A. ; Spiess, S. ; Lehner, A. ; Turgay, K. ; Mechtler, K. ; Charpentier, E. ; Clausen, T.

Science, 06/05/2009, Vol.324(5932), pp.1323-1327 [Tạp chí có phản biện]

ISSN: 0036-8075 ; E-ISSN: 1095-9203 ; DOI: http://dx.doi.org/10.1126/science.1170088

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  • Nhan đề:
    McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR
  • Tác giả: Fuhrmann, J. ; Schmidt, A. ; Spiess, S. ; Lehner, A. ; Turgay, K. ; Mechtler, K. ; Charpentier, E. ; Clausen, T.
  • Chủ đề: Bacteria ; Proteins ; Stresses ; Binding ; Kinases ; Genes ; Deoxyribonucleic Acid ; Biochemistry ; Miscellaneous Sciences (So) ; Article
  • Là 1 phần của: Science, 06/05/2009, Vol.324(5932), pp.1323-1327
  • Mô tả: All living organisms face a variety of environmental stresses that cause the misfolding and aggregation of proteins. To eliminate damaged proteins, cells developed highly efficient stress response and protein quality control systems. We performed a biochemical and structural analysis of the bacterial CtsR/McsB stress response. The crystal structure of the CtsR repressor, in complex with DNA, pinpointed key residues important for high-affinity binding to the promoter regions of heat-shock genes. Moreover, biochemical characterization of McsB revealed that McsB specifically phosphorylates arginine residues in the DNA binding domain of CtsR, thereby impairing its function as a repressor of stress response genes. Identification of the CtsR/McsB arginine phospho-switch expands the repertoire of possible protein modifications involved in prokaryotic and eukaryotic transcriptional regulation. [PUBLICATION ]
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0036-8075 ; E-ISSN: 1095-9203 ; DOI: http://dx.doi.org/10.1126/science.1170088

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