skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

Antioxidant Vitamins and Brain Dysfunction in Alcoholics

Gonzalez-Reimers, E. ; Fernandez-Rodriguez, C. M. ; Candelaria Martin-Gonzalez, M. ; Hernandez-Betancor, I. ; Abreu-Gonzalez, P. ; Jose de La Vega-Prieto, M. ; Elvira-Cabrera, O. ; Santolaria-Fernandez, F.

Alcohol and Alcoholism, 01/01/2014, Vol.49(1), pp.45-50 [Tạp chí có phản biện]

ISSN: 0735-0414 ; E-ISSN: 1464-3502 ; DOI: http://dx.doi.org/10.1093/alcalc/agt150

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    Antioxidant Vitamins and Brain Dysfunction in Alcoholics
  • Tác giả: Gonzalez-Reimers, E. ; Fernandez-Rodriguez, C. M. ; Candelaria Martin-Gonzalez, M. ; Hernandez-Betancor, I. ; Abreu-Gonzalez, P. ; Jose de La Vega-Prieto, M. ; Elvira-Cabrera, O. ; Santolaria-Fernandez, F.
  • Chủ đề: Vitamins ; Brain Atrophy ; Alcoholics ; Liver ; Antioxidants ; Dysfunction ; Article
  • Là 1 phần của: Alcohol and Alcoholism, 01/01/2014, Vol.49(1), pp.45-50
  • Mô tả: Aims: Alcohol induces cytokine secretion by Kupffer cells, which may exert also deleterious effects on distant organs, mediated in part by cytokine-derived increased production of reactive oxygen species (ROS). It is therefore important to assess antioxidant levels. The objective of this study is to analyse the relation of antioxidant vitamins with brain atrophy and cognitive dysfunction. Methods: In 77 alcoholic patients admitted for withdrawal syndrome, subjected to brain computed tomography (CT), and 19 controls, we determined antioxidant vitamin levels and analysed their relationships with data of brain atrophy and dysfunction. Searching for causes of altered vitamin levels, we also assessed liver function, nutritional status, eating habits, alcohol intake, proinflammatory cytokine (TNF-a, IL-6, IL-8) levels and malondialdehyde (MDA) levels. Results: Both retinol (vitamin A) and tocopherol (vitamin E) levels were decreased in alcoholics, the former in relation with liver failure, and the latter in relation with triglyceride levels and fat mass. Both were related to data of brain atrophy and cerebellar shrinkage (to which also IL-6 was significantly related). Conclusion: Among alcoholics, liver function impairment leads to altered serum vitamin A levels, which are related to brain alterations. Vitamin E levels are also decreased, but although in relation with liver function impairment, its decrease seems to be more dependent on nutritional status and irregular eating habits. Both vitamins are lower in patients with cerebellar atrophy and other features related to brain atrophy. Adapted from the source document.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0735-0414 ; E-ISSN: 1464-3502 ; DOI: http://dx.doi.org/10.1093/alcalc/agt150

Đang tìm Cơ sở dữ liệu bên ngoài...