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Metals and Inorganic Compounds

Physiologically Based Pharmacokinetic Modeling, Chapter 9, p.239-270

ISBN: 9780471478140 ; E-ISBN: 9780471478768 ; DOI: 10.1002/0471478768.ch9

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  • Nhan đề:
    Metals and Inorganic Compounds
  • Chủ đề: Toxicology ; Pbpk Modeling ; Metals ; Arsenic ; Lead ; Nickel ; Chromium ; Manganese ; Fluoride ; Radon ; Uranium ; Thorium ; Strontium ; Cadmium ; Potassium ; Rubidium ; Cesium ; Tritium ; Endogenous Compounds ; Essential Elements
  • Là 1 phần của: Physiologically Based Pharmacokinetic Modeling, Chapter 9, p.239-270
  • Mô tả: metals are prominent contaminants of the environment and important toxicants in many occupational settings. major societal issues surround the toxic effects of heavy metals (e.g., mercury and lead), metalloids (e.g., arsenic) and essential trace elements (e.g., zinc and manganese). these latter compounds, though essential for life, are toxic at high doses. for metals, patterns of toxicity are typically complex. both parent compounds and metabolites can have differing pathologic effects in a variety of target organs, and realistic pbpk models require corresponding complexity. as another challenge in developing pbpk models for these compounds, pharmacokinetic storage sites for metals can be unusual (e.g., bone), and accumulation in these tissues can result in long‐term health effects after exposure. this chapter includes a detailed description of pbpk models for arsenic, nickel, lead, and chromium, with emphasis on the unique aspects of each. the lead and chromium models are compared and contrasted to a similar pbpk model developed for fluoride (another bone‐seeking element, albeit non‐metal). finally, there is a brief discussion of compartment models developed for compounds such as iron and other endogenous compounds. this chapter also notes continuing research needs in extending and developing pbpk models for various metals.
  • Nơi xuất bản: Hoboken, NJ, USA: John Wiley & Sons, Inc.
  • Năm xuất bản: 2005
  • Ngôn ngữ: English
  • Số nhận dạng: ISBN: 9780471478140 ; E-ISBN: 9780471478768 ; DOI: 10.1002/0471478768.ch9

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