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6.24 - Metals and Cardiovascular Disease

Barchowsky, A.

Comprehensive Toxicology, Chapter 6.24, pp.447-463

ISBN: 978-0-08-046868-6 ; ISBN: 978-0-08-046884-6 ; DOI: 10.1016/B978-0-08-046884-6.00721-1

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  • Nhan đề:
    6.24 - Metals and Cardiovascular Disease
  • Tác giả: Barchowsky, A.
  • Chủ đề: arsenic ; angiogenesis ; antimony ; cadmium ; cardiovascular disease ; cobalt ; copper ; hypertension ; iron ; ischemic disease ; lead ; mercury ; metal ; metalloid ; nickel ; vanadium ; zinc
  • Là 1 phần của: Comprehensive Toxicology, Chapter 6.24, pp.447-463
  • Mô tả: Metals are among the oldest toxicants known to humans. Their impact on human health in general is well documented. However, their role in promoting cardiovascular diseases and their mechanisms for affects in heart and vascular tissues are often unrealized or controversial. The approach of using high dose toxicity studies that determine lethal dosages or acute toxicities in animals often confuses understanding of disease etiologies in humans, especially in understanding mechanisms of chronic disease promotion. There is increased appreciation that environmental exposures to metals or exposures even at occupational or therapeutic levels may have more subtle effects in causing or modifying chronic diseases. Exposures to metals are widespread and may produce greater effects in susceptible populations or when exposures occur during development. Mechanisms of metals or metalloid action are often thought to be mediated by nonspecific interactions with peptide or protein sulfhydryls, produced by random oxidant injury, or caused by disrupting the normal signaling of selective ion channels. While possibly true at the highest levels of exposure, recent epidemiological studies and studies in genetic rodent models indicate that pathogenic effects of metals on cell signaling are not random and cannot be accounted for by direct competition with endogenous ions or excessive oxidant-mediated injury. Resolution of the molecular understanding of these pathogenic effects and toxicities remains a challenge. This challenge is complicated by complex differential concentration- and time-dependent relationships for metal effects in different cell types, as well as a high degree of interactions between metals in common mixed exposures. This chapter will present pathogenic effects of metals in the heart and blood vessels with an emphasis on the cellular and molecular actions underlying disease or clinically significant toxicities that are directly linked to human exposures to metals. Essential endogenous metals, such as calcium, magnesium, and potassium that are critical for normal electrical conductance and cardiovascular function, will be discussed only indirectly.
  • Nơi xuất bản: Elsevier Ltd
  • Năm xuất bản: 2010
  • Ngôn ngữ: English
  • Số nhận dạng: ISBN: 978-0-08-046868-6 ; ISBN: 978-0-08-046884-6 ; DOI: 10.1016/B978-0-08-046884-6.00721-1

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