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Comparison of the antianginal efficacy of acebutolol and propranolol. A multicenter, randomized, double-blind placebo-controlled study

Dibianco, R ; Singh, S N ; Shah, P M ; Newton, G C ; Miller, R R ; Nahormek, P ; Costello, R B ; Laddu, A R ; Gottdiener, J S ; Fletcher, R D

Circulation, June 1982, Vol.65(6), pp.1119-28 [Tạp chí có phản biện]

ISSN: 0009-7322 ; PMID: 6804109 Version:1

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  • Nhan đề:
    Comparison of the antianginal efficacy of acebutolol and propranolol. A multicenter, randomized, double-blind placebo-controlled study
  • Tác giả: Dibianco, R ; Singh, S N ; Shah, P M ; Newton, G C ; Miller, R R ; Nahormek, P ; Costello, R B ; Laddu, A R ; Gottdiener, J S ; Fletcher, R D
  • Chủ đề: Acebutolol -- Therapeutic Use ; Angina Pectoris -- Drug Therapy ; Propranolol -- Therapeutic Use
  • Là 1 phần của: Circulation, June 1982, Vol.65(6), pp.1119-28
  • Mô tả: The effects of oral acebutolol, a cardioselective β-adrenergic blocking agent with partial agonist activity were compared with those of oral propranolol, a noncardioselective agent devoid of partial agonist activity, on the exercise tolerance and anginal pattern in 46 male patients with chronic stable angina pectoris. A 28-week, multicenter, placebo-controlled, randomized, double-blind, crossover study design was used. Each double-blind treatment phase was followed by a 2-week gradual drug-withdrawal phase and a placebo-controlled drug-free week. Angina frequency, nitroglycerin consumption and symptom-limited exercise tests were assessed throughout the study. Acebutolol and propranolol produced comparable levels of β blockade at 1650 ± 375 mg/day and 219 ± 50 mg/day (mean ± SD), respectively, as confirmed by a significant reduction in resting and peak exercise heart rates and rate-pressure products. Compared with placebo (acebutolol vs propranolol, NS), acebutolol produced a greater reduction in systolic, mean and diastolic blood pressures and a smaller reduction in resting heart rate than propranolol, presumably reflecting its partial agonist and cardioselective properties during similar dose-titration phases. Exercise duration and exercise work improved similarly with each agent. Acebutolol and propranolol significantly and comparably reduced anginal frequency (56% and 54%, respectively, p < .001) and weekly nitroglycerin consumption (57% and 47%, respectively, p < 0.01) compared with placebo. No clinical or laboratory side effects of acebutolol or propranolol necessitated drug withdrawal. We conclude that acebutolol is a well-tolerated and safe β-adrenergic blocking agent that possesses cardioselective and mild intrinsic sympathomimetic activities and compares favorably with propranolol in antianginal efficacy in patients with chronic stable angina.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0009-7322 ; PMID: 6804109 Version:1

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