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A comparison of oral milrinone, digoxin, and their combination in the treatment of patients with chronic heart failure

Dibianco, R ; Shabetai, R ; Kostuk, W ; Moran, J ; Schlant, R C ; Wright, R

The New England journal of medicine, 16 March 1989, Vol.320(11), pp.677-83 [Tạp chí có phản biện]

ISSN: 0028-4793 ; PMID: 2646536 Version:1

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  • Nhan đề:
    A comparison of oral milrinone, digoxin, and their combination in the treatment of patients with chronic heart failure
  • Tác giả: Dibianco, R ; Shabetai, R ; Kostuk, W ; Moran, J ; Schlant, R C ; Wright, R
  • Chủ đề: Cardiotonic Agents -- Administration & Dosage ; Digoxin -- Administration & Dosage ; Heart Failure -- Drug Therapy ; Pyridones -- Administration & Dosage ; Vasodilator Agents -- Administration & Dosage
  • Là 1 phần của: The New England journal of medicine, 16 March 1989, Vol.320(11), pp.677-83
  • Mô tả: We randomly assigned 230 patients in sinus rhythm with moderately severe heart failure to treatment with digoxin, milrinone, both, or placebo. The effects of each were compared during a 12-week, double-blind trial. Treatment with milrinone or digoxin significantly increased treadmill exercise time as compared with placebo (by 82 and 64 seconds respectively; 95 percent confidence limits, 44 and 123, and 30 and 100). Both treatments reduced the frequency of decompensation from heart failure, from 47 percent with placebo to 34 percent with milrinone (P less than 0.05; 95 percent confidence limits, 22 and 46) and 15 percent with digoxin (P less than 0.01; 95 percent confidence limits, 7 and 26). However, the clinical condition of 20 percent of the patients taking milrinone deteriorated within two weeks after treatment was begun, as compared with only 3 percent of those taking digoxin (P less than 0.05). The left ventricular ejection fraction at rest was not significantly changed by milrinone...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0028-4793 ; PMID: 2646536 Version:1

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