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Recognition of duplex RNA by helix-threading peptides

Gooch, Barry D ; Beal, Peter A

Journal of the American Chemical Society, 01 September 2004, Vol.126(34), pp.10603-10 [Tạp chí có phản biện]

ISSN: 0002-7863 ; PMID: 15327318 Version:1

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  • Nhan đề:
    Recognition of duplex RNA by helix-threading peptides
  • Tác giả: Gooch, Barry D ; Beal, Peter A
  • Chủ đề: Intercalating Agents -- Chemistry ; Oligopeptides -- Chemistry ; RNA, Double-Stranded -- Chemistry
  • Là 1 phần của: Journal of the American Chemical Society, 01 September 2004, Vol.126(34), pp.10603-10
  • Mô tả: Many important biological processes, from the interferon antiviral response to the generation of microRNA regulators of translation, involve duplex RNA. Small molecules capable of binding duplex RNA structures with high affinity and selectivity will be useful in regulating these processes and, as such, are valuable research tools and potentially therapeutic. In this paper, the synthesis and duplex RNA-binding properties of EDTA.Fe-modified peptide-intercalator conjugates (PICs) are described. Peptide appendages at the 4- and 9-positions of the planar acridine ring system render these PICs threading intercalators, directing the substituents into both grooves of double helical RNA simultaneously. Directed hydroxyl radical cleavage experiments conducted with varying RNA stem-loop structures indicate a preferred binding polarity with the N- and C-termini of the PIC in the minor and major grooves, respectively. However, this binding polarity is shown to be dependent on both the structure of...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0002-7863 ; PMID: 15327318 Version:1

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