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Prognostic importance of survivin in breast cancer

Kennedy, S M ; O'Driscoll, L ; Purcell, R ; Fitz-Simons, N ; Mcdermott, E W ; Hill, A D ; O'Higgins, N J ; Parkinson, M ; Linehan, R ; Clynes, M

British journal of cancer, 07 April 2003, Vol.88(7), pp.1077-83 [Tạp chí có phản biện]

ISSN: 0007-0920 ; PMID: 12671708 Version:1

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  • Nhan đề:
    Prognostic importance of survivin in breast cancer
  • Tác giả: Kennedy, S M ; O'Driscoll, L ; Purcell, R ; Fitz-Simons, N ; Mcdermott, E W ; Hill, A D ; O'Higgins, N J ; Parkinson, M ; Linehan, R ; Clynes, M
  • Chủ đề: Breast Neoplasms -- Chemistry ; Microtubule-Associated Proteins -- Analysis
  • Là 1 phần của: British journal of cancer, 07 April 2003, Vol.88(7), pp.1077-83
  • Mô tả: Survivin is a member of the inhibitor of apoptosis (IAP) family, and is also involved in the regulation of cell division. Survivin is widely expressed in foetal tissues and in human cancers, but generally not in normal adult tissue. This study examined the expression of surviving protein in a series of 293 cases of invasive primary breast carcinoma. Survivin immunoreactivity was assessed using two different polyclonal antibodies, and evaluated semiquantitatively according to the percentage of cells demonstrating distinct nuclear and/or diffuse cytoplasmic staining. Overall, 60% of tumours were positive for survivin: 31% demonstrated nuclear staining only, 13% cytoplasmic only, and 16% of tumour cells demonstrated both nuclear and cytoplasmic staining. Statistical analysis revealed that survivin expression was independent of patient's age, tumour size, histological grade, nodal status, and oestrogen receptor status. In multivariate analysis, nuclear survivin expression was a significant...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0007-0920 ; PMID: 12671708 Version:1

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