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The [alpha].sub.2-adrenoceptors mediating inhibition of the vasopressor sympathetic outflow in pithed rats: Pharmacological correlation with [alpha].sub.2A, [alpha].sub.2B and [alpha].sub.2C subtypes

Villamil - Hernandez, Ma. Trinidad ; Alcantara - Vazquez, Oscar ; Sanchez - Lopez, Araceli ; Centurion, David

European Journal of Pharmacology, Oct 15, 2013, Vol.718(1-3), p.245(8) [Tạp chí có phản biện]

ISSN: 0014-2999

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  • Nhan đề:
    The [alpha].sub.2-adrenoceptors mediating inhibition of the vasopressor sympathetic outflow in pithed rats: Pharmacological correlation with [alpha].sub.2A, [alpha].sub.2B and [alpha].sub.2C subtypes
  • Tác giả: Villamil - Hernandez, Ma. Trinidad ; Alcantara - Vazquez, Oscar ; Sanchez - Lopez, Araceli ; Centurion, David
  • Chủ đề: Norepinephrine
  • Là 1 phần của: European Journal of Pharmacology, Oct 15, 2013, Vol.718(1-3), p.245(8)
  • Mô tả: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ejphar.2013.08.025 Byline: Ma. Trinidad Villamil-Hernandez, Oscar Alcantara-Vazquez, Araceli Sanchez-Lopez, David Centurion Abstract: [alpha].sub.2-Adrenoceptors were first described as presynaptic receptors inhibiting the release of various transmitters from neurons in the central and peripheral nervous systems. In vitro studies have confirmed that [alpha].sub.2A, [alpha].sub.2B and [alpha].sub.2C subtypes inhibited noradrenaline release from postganglionic sympathetic neurons but no study has been reported their involvement in the vasopressor sympathetic outflow in vivo. Thus, this study analysed the subtype(s) involved in the inhibition produced by the [alpha].sub.2-adrenoceptor agonist, B-HT 933, on the vasopressor sympathetic outflow. Male Wistar pithed rats were pre-treated with i.v. bolus injections of gallamine (25mg/kg) and desipramine (50A[micro]g/kg) and prepared to stimulate the vasopressor sympathetic outflow (T.sub.7-T.sub.9) or to receive i.v. bolus of exogenous noradrenaline. Sympathetic stimulation or exogenous noradrenaline produced, respectively, frequency-dependent and dose-dependent vasopressor responses. I.v. continuous infusion of B-HT 933 (30[mu]g/kgmin) failed to modify the vasopressor responses to exogenous noradrenaline and inhibited those induced by preganglionic stimulation of the vasopressor sympathetic outflow at all frequencies of stimulation (0.03-3Hz). The sympatho-inhibition elicited by B-HT 933 was: (i) unaffected by vehicles (1ml/kg); (ii) partially antagonised by BRL44408 (300[mu]g/kg; [alpha].sub.2A), imiloxan (3000[mu]g/kg; [alpha].sub.2B) and/or JP-1302 (300[mu]g/kg; [alpha].sub.2C) given separately; and (iii) completely blocked by rauwolscine (300[mu]g/kg) or the combination of BRL44408 (300[mu]g/kg)+imiloxan (3000[mu]g/kg)+JP-1302 (300[mu]g/kg). The above doses of antagonists did not modify per se the sympathetically-induced vasopressor responses. These results suggest that the vasopressor sympatho-inhibition to B-HT 933 is primarily mediated by activation of [alpha].sub.2A/2B/2C-adrenoceptors in pithed rats. Author Affiliation: Departamento de Farmacobiologia, Cinvestav-Coapa, Czda. de los Tenorios No. 235, Col. Granjas-Coapa, Deleg. Tlalpan, 14330 Mexico D.F., Mexico Article History: Received 31 May 2013; Revised 4 July 2013; Accepted 5 August 2013
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0014-2999

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