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Fluvoxamine enhances prefrontal dopaminergic neurotransmission in adrenalectomized/castrated mice via both 5-HT reuptake inhibition and [sigma].sub.1 receptor activation.(Report)

Ago, Yukio ; Yano, Koji ; Hiramatsu, Naoki ; Takuma, Kazuhiro ; Matsuda, Toshio

Psychopharmacology, Oct, 2011, Vol.217(3), p.377(10) [Tạp chí có phản biện]

ISSN: 0033-3158

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  • Nhan đề:
    Fluvoxamine enhances prefrontal dopaminergic neurotransmission in adrenalectomized/castrated mice via both 5-HT reuptake inhibition and [sigma].sub.1 receptor activation.(Report)
  • Tác giả: Ago, Yukio ; Yano, Koji ; Hiramatsu, Naoki ; Takuma, Kazuhiro ; Matsuda, Toshio
  • Chủ đề: Child Development -- Analysis ; Neurons -- Analysis ; Paroxetine -- Analysis ; Dopamine -- Analysis ; Universities And Colleges -- Analysis ; Norepinephrine -- Analysis
  • Là 1 phần của: Psychopharmacology, Oct, 2011, Vol.217(3), p.377(10)
  • Mô tả: Byline: Yukio Ago (1), Koji Yano (1), Naoki Hiramatsu (1), Kazuhiro Takuma (1), Toshio Matsuda (1,2,3) Keywords: Fluvoxamine; [sigma].sub.1 receptor; c-Fos; Adrenalectomy/castration; Dopamine (DA); Prefrontal cortex Abstract: Rationale Fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor (SSRI) and an agonist for the [sigma].sub.1 receptors, increases extracellular monoamines in the prefrontal cortex, but it is not known whether the [sigma].sub.1 receptor is involved in the neurochemical effect of fluvoxamine. Objectives In view of the fact that circulating steroids exert a tonic modulatory effect on [sigma].sub.1 receptor-mediated effects, the present study examines the effects of fluvoxamine on prefrontal extracellular monoamine levels in adrenalectomized/castrated mice lacking the peripheral sources of steroids. Results Fluvoxamine-induced increases in the extracellular levels of dopamine (DA), but not of 5-HT and noradrenaline, were significantly higher in adrenalectomized/castrated than in sham-operated mice, and this effect was blocked by BD1047, a selective [sigma].sub.1 receptor antagonist. In contrast, the effects of paroxetine, an SSRI without affinity for the [sigma].sub.1 receptors, and (+)-SKF-10,047, a selective [sigma].sub.1 receptor agonist, on the extracellular monoamine levels did not differ between adrenalectomized/castrated and sham-operated mice, while the increase in extracellular DA levels induced by co-administration of these drugs was higher in adrenalectomized/castrated than in the control mice. Moreover, fluvoxamine increased c-Fos expression, a marker of neuronal activity, in the prefrontal cortex of adrenalectomized/castrated mice, and this effect was blocked by BD1047. The similar increase in c-Fos expression was observed by co-administration of paroxetine and (+)-SKF-10,047. Conclusions These findings suggest that fluvoxamine enhances prefrontal dopaminergic neurotransmission via both 5-HT reuptake inhibition and [sigma].sub.1 receptor activation under the circulating neuroactive steroid-deficient conditions. Author Affiliation: (1) Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871, Japan (2) Department of Experimental Disease Model, The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan (3) United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan Article History: Registration Date: 30/03/2011 Received Date: 26/01/2011 Accepted Date: 27/03/2011 Online Date: 13/04/2011 Article note: Electronic supplementary material The online version of this article (doi: 10.1007/s00213-011-2293-5) contains supplementary material, which is available to authorized users.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0033-3158

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