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Expression of Molecular Markers in the Tumor and Survival Prognosis in Osteosarcoma.(Report)

Boulytcheva, I. V. ; Soloviev, Yu. N. ; Kushlinskii, N. E. ; Mahson, A. N.

Bulletin of Experimental Biology and Medicine, Dec, 2010, Vol.150(2), p.237(6) [Tạp chí có phản biện]

ISSN: 0007-4888

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  • Nhan đề:
    Expression of Molecular Markers in the Tumor and Survival Prognosis in Osteosarcoma.(Report)
  • Tác giả: Boulytcheva, I. V. ; Soloviev, Yu. N. ; Kushlinskii, N. E. ; Mahson, A. N.
  • Chủ đề: Cancer Research ; Tumors ; Tumor Proteins ; Vascular Endothelial Growth Factor ; Osteosarcoma
  • Là 1 phần của: Bulletin of Experimental Biology and Medicine, Dec, 2010, Vol.150(2), p.237(6)
  • Mô tả: Byline: I. V. Boulytcheva (1), Yu. N. Soloviev (2), N. E. Kushlinskii (2), A. N. Mahson (1) Keywords: osteosarcoma; expression; p53; VEGF; Flt-1/VEGFR1 Ab-1; EGFR; HER-2/neu Abstract: Immunohistochemical study of p53, VEGF, Flt-1/VEGFR1 Ab-1, EGFR, HER-2/neu, Bax, and Cox-2 expression in osteosarcomas was carried out in 40 patients aged 16-70 years. Expression of p53 was detected in 27.5% tumors, VEGF in 15%, Flt-1/VEGFR1 Ab-1 in 97.5%, EGFR in 52.5%, HER-2/neu in 32.5%, Bax in 77.8%, and Cox-2 in 32.3% tumors. Multifactorial analysis showed that the expression of HER-2/neu (p=0.004), p53 (p=0.01), and Cox-2 (p=0.04) in osteosarcomas significantly correlated with unfavorable prognosis for overall survival, while HER-2/neu (p=0.02) and Cox-2 (p=0.003) with relapse-free survival. Analysis of HER-2/neu, p53, and Cox-2 expression in the primary tumor should be taken into consideration in the treatment of patients with osteosarcoma. Author Affiliation: (1) Department of Pathological Anatomy, Moscow Oncological Hospital No. 62, Moscow, Russia (2) N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia Article History: Registration Date: 02/12/2010 Received Date: 21/06/2009 Online Date: 21/12/2010 Article note: Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 150, No. 8, pp. 202-207, August, 2010
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0007-4888

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