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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

Hsu, P. P. ; Kang, S. A. ; Rameseder, J. ; Zhang, Y. ; Ottina, K. A. ; Lim, D. ; Peterson, T. R. ; Choi, Y. ; Gray, N. S. ; Yaffe, M. B. ; Marto, J. A. ; Sabatini, D. M.

Science, 06/10/2011, Vol.332(6035), pp.1317-1322 [Tạp chí có phản biện]

ISSN: 0036-8075 ; E-ISSN: 1095-9203 ; DOI: http://dx.doi.org/10.1126/science.1199498

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  • Nhan đề:
    The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
  • Tác giả: Hsu, P. P. ; Kang, S. A. ; Rameseder, J. ; Zhang, Y. ; Ottina, K. A. ; Lim, D. ; Peterson, T. R. ; Choi, Y. ; Gray, N. S. ; Yaffe, M. B. ; Marto, J. A. ; Sabatini, D. M.
  • Chủ đề: Kinases ; Proteomics ; Proteins ; Signaling ; Cellular Biology
  • Là 1 phần của: Science, 06/10/2011, Vol.332(6035), pp.1317-1322
  • Mô tả: The protein kinase mTOR functions in protein complexes (mTORC1 and mTORC2) that are activated in response to agents such as growth factors and insulin and has important roles in regulating many physiological responses, including cell growth, proliferation, metabolism, and cell survival (see the Perspective by Yea and Fruman ). Hsu et al. (p. 1317) and Yu et al. (p. 1322) conducted proteomic screens to identify substrates of mTORC1 and mTORC2 kinases. Numerous proteins that appear to be direct substrates were identified, including a new mTOR substrate, Grb10. Grb10 is an adaptor molecule that functions in the formation of signaling complexes associated with growth factor receptor tyrosine kinases. The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We defined the mTOR-regulated phosphoproteome by quantitative mass spectrometry and characterized...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0036-8075 ; E-ISSN: 1095-9203 ; DOI: http://dx.doi.org/10.1126/science.1199498

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